Losartan/ Hydrochlorothiazide Color Shape Engraving NDC 0006-xxxx-xx Bottle/ 30 Bottle/ 90 Bottle/ 1000 50/12.5 mg yellow oval losartan /12.5 mg white oval /25 mg light yellow oval n/a Store at 25C (77F excursions permitted to losartan 15-30C (59-86F) see USP Controlled Room Temperature. These include cough or losartan cold drugs, diet hydrochlorothiazide pills, stimulants, ibuprofen or like products, and some losartan natural products or aids. A typical adult dose losartan may hydrochlorothiazide cause levels of losartan this drug to hydrochlorothiazide be higher hydrochlorothiazide side effects than normal in hydrochlorothiazide your body. In addition, blood pressure reductions in both treatment groups were losartan consistent between Black and non-Black patients. Pregnancy and Hyzaar, hyzaar losartan contains a black-box warning because it may harm an unborn baby. Are not passing urine. Do not share your drugs with losartan others and do not take anyone else's drugs. For people with hydrochlorothiazide diabetes: Your hydrochlorothiazide doctor hydrochlorothiazide may adjust the hydrochlorothiazide doses of hydrochlorothiazide your diabetes drugs while youre taking this medicine. Serious side effects, call losartan your doctor right away if you losartan have serious side effects. Tell your doctor or get medical help right away if you have any of hydrochlorothiazide the losartan following signs or symptoms that may be related to a very hydrochlorothiazide bad side effect: Signs hydrochlorothiazide of an allergic reaction, like rash; hives; itching; red. Your dose, form, and how hydrochlorothiazide weight loss hydrochlorothiazide often you take it will depend on: your age losartan the losartan condition being treated how severe your condition is other losartan medical conditions you have how you react to the losartan first dose Drug forms and strengths Generic: Losartan/hydrochlorothiazide. Indirectly, the diuretic action of hydrochlorothiazide reduces plasma volume, with consequent increases in plasma renin activity, increases in aldosterone secretion, increases in urinary potassium losartan loss, and decreases in serum potassium. Medical Disclaimer Next Side Effects Add to My Med List More about hydrochlorothiazide/losartan Consumer resources Other brands: Hyzaar Professional resources Related treatment guides. From Heart Health Resources Featured Centers Health Solutions From Our Sponsors Report Problems to the Food and Drug Administration You are encouraged to report negative side effects of prescription drugs to the FDA. What hydrochlorothiazide should hydrochlorothiazide dosage I tell my doctor before taking hyzaar? If you have an allergy to losartan, hydrochlorothiazide, or any other part of losartan and hydrochlorothiazide. This is not a complete list of side effects. Talk with your doctor before using OTC products that may raise blood pressure. Check your blood sugar regularly as directed and share the results with your doctor. This drug should only be used during pregnancy in serious cases where it's needed to treat a dangerous condition in the mother. Conversion of losartan to its active metabolite after intravenous administration is not affected by ketoconazole, an inhibitor of P450 e AUC of active metabolite following oral losartan was not affected by erythromycin, an inhibitor of P450 3A4. How it works, this drug belongs to a class of drugs called angiotensin II receptor blockers and thiazide diuretics. Patients who had typical ACE-inhibitor cough when challenged with lisinopril, whose cough disappeared on placebo, were randomized to losartan 50 mg, lisinopril 20 mg, or either placebo (one study, n97) or 25 hydrochlorothiazide weight loss mg hydrochlorothiazide (n135). Hepato-biliary disorders: Jaundice (intrahepatic cholestatic jaundice). Keep all appointments with your doctor and laboratory. Low blood potassium ( hypokalemia ) can hydrochlorothiazide increase losartan the toxicity of digoxin ( Lanoxin ). For a complete list, ask your doctor or pharmacist. In nonpregnant rats dosed at 135 mg/kg/day for 7 losartan days, systemic exposure (AUCs) for losartan and its active metabolite were approximately 66 and 26 times the exposure achieved in man at the maximum recommended human daily dosage (100 mg). Left Ventricular Hypertrophy (LVH) is an enlargement of the walls of the left chamber of the heart (the heart's main pumping chamber). Contraindications hyzaar is contraindicated: In patients who are hypersensitive to any component of this product. The most likely manifestation of overdosage would be hypotension and tachycardia losartan ; bradycardia could occur from parasympathetic (vagal) stimulation. Initiate a patient whose blood pressure is inadequately controlled with hydrochlorothiazide 25 mg once daily, or is controlled but who experiences hypokalemia with this regimen, on hyzaar 50/12.5 once daily, reducing the dose of hydrochlorothiazide without reducing the overall expected antihypertensive response. This drug should only be used if the potential risk losartan to the fetus is acceptable given the drugs potential benefit. Your doctor will monitor your kidney function and adjust your medication as needed. Treatment with losartan resulted in a 13 reduction (p0.021) in risk of the primary endpoint compared to the atenolol group; this difference was primarily the result of an effect on fatal and nonfatal stroke. See What is the most important information hydrochlorothiazide I should know about hyzaar? Relative risk reduction from blood pressure reduction is similar across populations with varying absolute risk, so the absolute benefit is greater in patients who are at higher risk independent of their hypertension (for example, patients with diabetes or hyperlipidemia. Fluconazole, an inhibitor of cytochrome P450 2C9, decreased the AUC of the active metabolite by approximately 40, but increased the AUC of losartan by approximately 70 following multiple doses. Correct volume or salt depletion prior hydrochlorothiazide to administration of hyzaar. Postsympathectomy Patients The antihypertensive effects of the drug may be enhanced in the postsympathectomy patient. Hyzaar may increase your risk of dehydration. This is a combination of two drugs in a single form. Tell your doctor if you have too much sweat, fluid loss, throwing up, or loose stools. Store in a dry place. Hyzaar and certain other medicines may interact with each other. Be careful going up and down stairs. High blood pressure can losartan occur if you stop hydrochlorothiazide taking this drug too suddenly. If you are breast-feeding or plan to breast-feed. Hyperuricemia may occur or frank gout may be precipitated in patients receiving thiazide therapy. Anaphylactic reactions have been hydrochlorothiazide reported. Cardiac disorders: Palpitation, tachycardia. Be ready to tell or show what was taken, how much, and when it happened. The drug information contained herein is subject to change and is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse losartan effects. In the unusual case that there is no appropriate alternative to therapy with drugs affecting the reninangiotensin system for a particular patient, apprise the mother of the potential risk to the fetus. Generic Name: Losartan losartan and Hydrochlorothiazide (loe SAR tan hye droe klor oh thye a zide). Cozaar is a newer type of blood pressure medicine known hydrochlorothiazide as an angiotensin II receptor blocker, or ARB for short. All possible dosages hydrochlorothiazide and forms may not be included here. Hyzaar can cause harm or death to an unborn baby. Combining hctz with corticosteroids may increase the risk for low levels of blood potassium and other electrolytes. If you are 65 or older, use losartan and hydrochlorothiazide with care. Cholestyramine and colestipol resins Absorption of hydrochlorothiazide is impaired in the presence of anionic exchange resins. This drug may make you dizzy. Renal Insufficiency Losartan Following oral administration, plasma concentrations and AUCs of losartan and its active metabolite are increased by 50-90 in patients with mild (creatinine clearance of 50 to 74 mL/min) or moderate (creatinine clearance 30 to 49 mL/min) renal insufficiency. A new or worsening condition called systemic lupus erythematosus (Lupus; SLE) Eye problems. Your dose depends on the dose of the blood pressure drug that you were taking before. Renal Impairment Changes in renal function have been reported in susceptible individuals see dosage AND administration, warnings AND precautions, and clinical pharmacology. Exchange transfusion or dialysis may be required hydrochlorothiazide as means of reversing hypotension and/or substituting for disordered renal function. Adverse events were somewhat more frequent in the elderly compared to non-elderly patients for both the losartan-hydrochlorothiazide and the control groups see clinical pharmacology. Lie down if you feel faint or dizzy. What are some things I need to know or do while I take Losartan and Hydrochlorothiazide? If you are on a low-salt or salt-free diet, talk with your doctor. Drink lots of noncaffeine liquids unless told to drink less liquid by your doctor. Respiratory, thoracic and mediastinal disorders: Nasal congestion, pharyngitis, sinus disorder, respiratory distress (including pneumonitis and pulmonary edema hydrochlorothiazide ). Just take the next dose at your regular time. Disclaimer: Our goal is to provide you with the most relevant and current information. Dont store this medication in moist or damp areas, such as bathrooms. Hyzaar Warnings, before taking Hyzaar, tell your doctor if you have, or have ever had: Kidney disease, problems with urination, liver disease. If you have any questions about losartan and hydrochlorothiazide, please talk with your doctor, nurse, pharmacist, or other health hydrochlorothiazide 12.5 care provider. It is converted, in part, to an active carboxylic acid metabolite that is responsible hydrochlorothiazide dosage for most of the angiotensin II receptor antagonism that follows losartan treatment. Alcohol or marijuana can make you more dizzy. What do I need to tell my doctor before I take Losartan and Hydrochlorothiazide? For people with liver disease: You shouldnt take this drug if you have liver disease. Check with your doctor or pharmacist hydrochlorothiazide hydrochlorothiazide if you are not sure if a drug you take has aliskiren. Active ingredients: losartan potassium, hydrochlorothiazide Inactive ingredients: microcrystalline cellulose, lactose hydrous, pregelatinized starch, magnesium stearate, hydroxypropyl cellulose, hypromellose, titanium dioxide. Hydrochlorothiazide had no adverse effects on the fertility of mice and rats of either sex in studies wherein these species were exposed, via their diet, to doses of up to 100 and 4 mg/kg, respectively, prior to mating and throughout gestation. Be sure to avoid doing this when the weather is very hot or very cold. Refills A prescription for this medication is refillable. Allergy warning This drug can cause a severe allergic reaction. The more common side effects that occur with losartan/hydrochlorothiazide include: upper respiratory infection, such as the common cold dizziness cough back pain, if these effects are mild, they may go away within a few days or a couple of weeks. You may also be more likely to have side effects of this drug. If blood pressure remains uncontrolled after about 3 weeks of therapy, increase the dose to two tablets of hyzaar 50/12.5 once daily or one tablet of hyzaar 100/25 once daily. For seniors: Older adults may process drugs more slowly. Medication Guide patient information hyzaar (HY-zar) (losartan potassium and hydrochlorothiazide tablets) 50/12.5 mg, 100/12.5 mg, 100/25 mg Read losartan the Patient Information that comes with hyzaar before you start taking it and each time you get a refill. Watch for gout attacks. Compared to normal subjects, the total plasma clearance of losartan in patients with hepatic insufficiency was about 50 lower, and the oral bioavailability was about doubled. Follow all instructions closely. Losartan blocks the action of angiotensin II, a chemical in your body that causes your blood vessels to tighten and narrow. Talk to your healthcare losartan provider about how much water you should drink throughout the day. Its given when one drug isnt enough to lower your blood pressure. Talk to your doctor if youre pregnant or planning to become pregnant. Symptoms include: trouble breathing hydrochlorothiazide swelling of your throat or tongue hives If you develop these symptoms, call 911 hydrochlorothiazide or go to the nearest emergency room. Hyzaar is not usually the first medicine used to treat high blood pressure. (Merck Sharp Dohme Corp. It may be given to you for other reasons. It works by blocking a substance in the body that causes the blood vessels to tighten. Hyzaar 50/12.5 and hyzaar 100/25 also contain D C yellow. There may be drug take-back programs in your area. Biliary excretion contributes to the elimination of losartan and its metabolites.
Hydrochlorothiazide 12.5 mg
If hydrochlorothiazide you go out in hot weather, especially if you are exercising, avoid becoming overheated or hydrochlorothiazide dehydrated. Hydrochlorothiazide hCTZ ) is a diuretic often prescribed for the hydrochlorothiazide hydrochlorothiazide treatment of high blood pressure and fluid retention. Overdosage hydrochlorothiazide The most common signs and symptoms observed are those caused by electrolyte depletion (hypokalemia, hypochloremia, hyponatremia) and dehydration resulting from excessive diuresis. Nervous System/Psychiatric: Vertigo, paresthesia, hydrochlorothiazide dizziness, headache, restlessness. Common hydrochlorothiazide side effects may include: nausea, hydrochlorothiazide vomiting, loss of appetite; diarrhea, constipation; muscle spasm; or hydrochlorothiazide dizziness, headache. SingleCare, a leading online service for prescription, dental, and vision discounts, has partnered with most major pharmacies around the hydrochlorothiazide country to help you save up to 80 percent hydrochlorothiazide off prescription costs. Refer to the package insert for lithium preparations before use of such preparations with hydrochlorothiazide. Because of the potential for serious adverse reactions in nursing infants, a decision should be made whether to discontinue nursing or to discontinue hydrochlorothiazide, taking into account the importance of the drug to the mother. Gelatin capsules contain D C Red. Special Senses Transient blurred vision, xanthopsia. Most blood pressure lowering medications, including hydrochlorothiazide, are prescribed together with other hypertensive products, along with dietary restrictions, exercise, and, in some cases, weight hydrochlorothiazide loss. Drug Interactions When given concurrently the following drugs may interact with thiazide diuretics. Tell your doctor about all your current medicines and any you start or stop using, especially: cholestyramine, colestipol; insulin or oral diabetes medicine; lithium; other blood pressure medications; steroid medicine; or nsaids (nonsteroidal anti-inflammatory drugs)-aspirin, ibuprofen (Advil, Motrin naproxen (Aleve celecoxib, diclofenac. Pregnancy Teratogenic Effects Pregnancy Category B: Studies in which hydrochlorothiazide was orally administered to pregnant mice and rats during their respective periods of major organogenesis at doses up to 30 mg hydrochlorothiazide/kg, respectively, provided no evidence of harm to the fetus. Hydrochlorothiazide had no adverse effects on the fertility of mice and rats of either sex in studies wherein these species were exposed, via their diet, to doses of up to 100 and 4 mg/kg, respectively, prior to conception and throughout gestation. With an intermittent schedule, excessive response and the resulting undesirable electrolyte imbalance are less likely to occur. Hydrochlorothiazide is usually taken once per day. If progressive renal impairment becomes evident, consider withholding or discontinuing diuretic therapy. Hypersensitivity to this product or other sulfonamide derived drugs is also contraindicated. Thiazides do not affect normal blood pressure. Patients usually do not require doses in excess of 50 mg of Hydrochlorothiazide daily when used concomitantly with other antihypertensive agents. Taking this medicine with other drugs that make you light-headed can worsen this effect. Nervous System/Psychiatric : Vertigo, paresthesia, dizziness, headache, restlessness. Cardiovascular : Hypotension including orthostatic hypotension (may be aggravated by alcohol, barbiturates, narcotics or antihypertensive drugs). Hyperuricemia hydrochlorothiazide Hyperuricemia or acute gout may be precipitated in certain patients hydrochlorothiazide receiving thiazide diuretics. In the event of overdosage, symptomatic and supportive measures should be employed. . Stop taking hydrochlorothiazide as soon as you find out you're pregnant. If further titration is required,.5 mg increments should be utilized. Protect from light, moisture, freezing, -20C (-4F). In actual salt depletion, appropriate replacement is the therapy of choice. Hydrochlorothiazide may also be prescribed to treat hydrochlorothiazide calcium-containing kidney stones because it decreases the amount of calcium excreted by the kidneys in the urine, thus reducing the amount of calcium available to form stones. However, if you take this medicine during pregnancy, your newborn baby may develop jaundice or other problems. Therefore, when Hydrochlorothiazide and non-steroidal anti-inflammatory agents are used concomitantly, the patient should be observed closely to determine if the desired effect of the diuretic is obtained. Digestive : Pancreatitis, jaundice ( intrahepatic cholestatic jaundice diarrhea, vomiting, sialadenitis, cramping, constipation, gastric irritation, nausea, anorexia.
Side effects of hydrochlorothiazide
Picture of Kidney Stone Diagnosis, the diagnosis of kidney stones is suspected by hydrochlorothiazide the typical pattern of symptoms when other possible causes of the abdominal. It is usually taken once a day, although it is sometimes taken two or three times a day. For seniors: Older adults effects may process drugs more slowly. Please check for these effects on your body side when using Hydrochlorothiazide. It is not known if hydrochlorothiazide will harm your unborn baby. Explore 10 food swaps for heart-wise dining. Pickkers P, Schachter M, Hughes AD, Feher MD, Sever PS "Thiazide-induced hyperglycaemia: a role for calcium-activated potassium channels?" Diabetologia 39 (1996 861-4. If youre side curious about how this drug might interact with hydrochlorothiazide something else youre side taking, talk to your doctor side or pharmacist. Hydrochlorothiazide oral tablet doesnt cause drowsiness but effects it can cause other side effects effects effects. Clinical monitoring During treatment with this drug, your doctor may check your potassium levels. If theyre more severe or dont go side away, talk to your doctor or pharmacist. Associated symptoms include dyspnea, hypoxia, respiratory distress, wheezing, cough, tachypnea, dizziness, nausea, vomiting, diarrhea, and effects hypotension. This drug is cleared from your body by your kidneys. Tell your doctor if any of these symptoms are severe or do not go away: muscle weakness dizziness cramps constipation thirst stomach pain nausea vomiting diarrhea loss of appetite headache hair loss sexual dysfunction (impotence) If you experience any. Warnings for people with certain health conditions For people with kidney problems: Use caution when taking hydrochlorothiazide if you have poor kidney function. Taking the drug this way lowers your risk of an imbalance in your electrolytes. Do not drive, use machinery, or do anything that needs alertness until you can do it safely. The eruption resolved upon discontinuation of hctz, but she later developed a higher ANA titer associated with symptomatic diffuse interstitial pulmonary infiltrates. Kidney Stones (nephrolithiasis) Kidney stones are solid masses of crystalline material that form in the kidneys. It's manufactured by several companies, including Mylan, Vintage Pharmaceuticals, and Watson Labs. Your doctor will monitor your blood effects pressure at your checkups. What are you taking Hydrochlorothiazide for? They have a similar chemical structure and are often used to treat similar conditions. Respiratory side : Allergic pneumonitis, pulmonary edema, respiratory distress. Before having surgery, tell your doctor or dentist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products). See a picture of the Heart and learn more. All possible dosages and forms may not be included here. (This article covers many, hydrochlorothiazide but not all, of the possible side effects with hydrochlorothiazide.